Glutathione is the body's most powerful antioxitant. The food you eat can help increase your glutathione levels because certain amount of glutathione is found in almost all fruits and vegetables. Most oral glutathione supplements are ineffective because your stomach enzymes tend to degrade the glutathione before your gut even gets to absorb and deliver it to the right cells.
Bulletproof Glutathione Force uses a new, proven drug delivery composition to target glutathione into gut cells and hold them in place until released into the blood. In this patented delivery technology, glutathione binds to a peptide called Lactoferrin. Lactoferrin also crosses your intestinal mucosa through a process called Cell Receptor Mediated Endocytosis (CRME) that allows it to deliver iron to blood plasma3. Binding Glutathione to lactoferrin allows the Glutathione to be more readily available for absorption into the intestinal mucosa.
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About glutathione
Glutathione is found in every cell and protects the body from inflammation, toxins and pathogens. When the body does not produce enough glutathione, becomes normal healthy functions and immune critically impaired (1).
How glutathione optimizes the central nervous system
Glutathione may help improve your short-term brain function, long-term memory, and help protect against cognitive decline. Glutathione helps counterbalance inflammatory effects of toxins in the brain that inhibit optimal brain function. There’s even evidence that maintaining higher glutathione levels is associated with healthier aging (2). Other studies indicate that degenerative aging is associated with oxidative stress, a sign that glutathione levels are depleted(3)(4).
How glutathione detoxifies the body
Glutathione is needed to help bind and remove toxins from every tissue in your body. If you don’t have enough glutathione, toxins may build up in the body. Some of the best evidence behind the powerful detoxifying effects of glutathione comes from drug research.
Acetaminophen poisoning is one of the most common drug related problems in developed countries. Acetaminophen depletes mitochondrial glutathione levels, which makes them more vulnerable to oxidative stress (5). In health care can give buildingblocks to glutathione to help protect people who’ve consumed too much acetaminophen from liver damage, and to remove the drugs from their system (6) (7). This is because glutathione is one of the most powerful natural detoxifying agents.
How glutathione promotes cardiovascular health
Studies have shown that low glutathione levels are associated with an increased risk of poor cardiovascular health (8). People with high tryglycerides typically have lower glutathione levels (9). When blood cells from people with compromised arteries are incubated with glutathione, they become less prone to stick together. Inside the body, this means the cells would be less likely to cause clots and heart issues (10) (11).
Why glutathione helps protect your gut
Research has shown that glutathione supplements may help improve gut health by decreasing oxidative stress. This may help promote proper digestion and intestinal functions (12) (13) (14). Some research even suggests that glutathione may help support the gut issues in people who are gluten intolerant (15).
How glutathione fights infections
Studies have found that glutathione supplements may help improve immune function by reducing oxidative stress in the immune system’s cells (16) (17).Your body needs a strong immune system to fight off infections, and good control of its immune system to keep it from overreacting.
How glutathione helps protect your body from heavy metal poisoning
Heavy metals like mercury damage cells and decrease performance. Heavy metals are present in many household items and in some cosmetics (some makeup and deodorant products) and foods (some fish). Glutathione helps detoxify mercury, cadmium, and arsenic in at least two ways: it increases the cells’ ability to resist the toxic effects of heavy metals, and it helps remove them from the body (18) (19). The human body isn’t very good at getting rid of toxic heavy metals, so they often build-up and decrease performance.
How Glugathione protects your body from alcohol damage
Sometimes, you probably expose yourself to some toxins on purpose – like alcohol. There’s nothing wrong with a drink every now and then, but long-term alcohol consumption is not good for you. Alcohol depletes glutathione levels, and can make your cells more susceptible to oxidative stress (20).
How Glutathione Force Helps Prevent Aging
Inflammation is tied to aging, which may be why people with high glutathione levels tend to live longer than those with low levels (21).
Some research indicates that damage to the power plants of your cells – the mitochondria, is a key factor in aging. Your body needs glutathione to protect your mitochondria, and when you don’t have enough, they can get damaged. This is especially true for liver cells. When mitochondria are low in glutathione, the liver is more susceptible to the negative effects of toxins (22).
Is it dangerous to take antioxidants?
The advantage of taking supplements of antioxidants has previously been questioned in the media and concerns have been raised that they could aggravate cancer (25). At the beginning of the year published a study that showed that high doses of eg one form of vitamin E (alpha-tocopherol) led to worsening of lung cancer in mice (26). Below is a video with a Ph.D. Ronda Patrick's where she puts the results in context and explains the studies weaknesses. She reveals, among other things that there are two main forms of vitamin E (alpha and gamma tocopherol) having separate functions. Taking high doses of alpha-tocopherol can actually deplete gamma-tocopherol levels, resulting in negative effects that can lead to cancer.
Our body is a large continuous chemical reaction. It requires adequate amounts of many different kinds of nutrients that fuel for these reactions. Supplements are good to fix defects and provide additional support. But the key to our health is dependent on a good base with lifestyle factors such as nutrient-rich foods.
/Christine Ribbing
1) A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Friesen C, Kiess Y, Debatin KM. Cell Death Differ. 2004 Jul;11 Suppl 1:S73-85.
2) Gender differences in glutathione metabolism in Alzheimer's disease. Liu H, Harrell LE, Shenvi S, Hagen T, Liu RM. J Neurosci Res. 2005 Mar 15;79(6):861-7.
3) Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress. Viña J, Lloret A, Ortí R, Alonso D. Mol Aspects Med. 2004 Feb-Apr;25(1-2):117-23
4) Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ. J Neurochem. 2005 May;93(4):1047-56.
5) Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat. Vendemiale G, Grattagliano I, Altomare E, Turturro N, Guerrieri F. Biochem Pharmacol. 1996 Oct 25;52(8):1147-54.
6) When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose. Salgia AD, Kosnik SD. Postgrad Med. 1999 Apr;105(4):81-4, 87, 90.
7) Analgesics and glutathione. Lauterburg BH. Am J Ther. 2002 May-Jun;9(3):225-33. Review.
8) Nutritional regulation of glutathione in stroke. Paterson PG, Juurlink BH. Neurotox Res. 1999 Dec;1(2):99-112.
9) Low blood glutathione levels in acute myocardial infarction. Kharb S. Indian J Med Sci. 2003 Aug;57(8):335-7.
10) Glutathione (GSH) improved haemostatic and haemorheological parameters in atherosclerotic subjects. Coppola L, Grassia A, Giunta R, Verrazzo G, Cava B, Tirelli A, D'Onofrio F. Drugs Exp Clin Res. 1992;18(11-12):493-8.
11) Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation. Kugiyama K, Ohgushi M, Motoyama T, Hirashima O, Soejima H, Misumi K, Yoshimura M, Ogawa H, Sugiyama S, Yasue H. Circulation. 1998 Jun 16;97(23):2299-301.
12) Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Sido B, Hack V, Hochlehnert A, Lipps H, Herfarth C, Dröge W. Gut. 1998 Apr;42(4):485-92.
13) Redox state and O2*- production in neutrophils of Crohn's disease patients. Biagioni C, Favilli F, Catarzi S, Marcucci T, Fazi M, Tonelli F, Vincenzini MT, Iantomasi T. Exp Biol Med (Maywood). 2006 Feb;231(2):186-95.
14) Glutathione metabolism in Crohn's disease. Iantomasi T, Marraccini P, Favilli F, Vincenzini MT, Ferretti P, Tonelli F. Biochem Med Metab Biol. 1994 Dec;53(2):87-91
15) Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. Stojiljković V, Todorović A, Pejić S, Kasapović J, Saicić ZS, Radlović N, Pajović SB. Clin Biochem. 2009 Sep;42(13-14):1431-7. doi: 10.1016/j.clinbiochem.2009.06.009. Epub 2009 Jun 25.
16) Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Bounous G, Molson J. Med Hypotheses. 1999 Oct;53(4):347-9.
17) Chronic fatigue syndrome: oxidative stress and dietary modifications. Logan AC, Wong C. Altern Med Rev. 2001 Oct;6(5):450-9. Review.
18) Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Patrick L. Altern Med Rev. 2002 Dec;7(6):456-71. Review.
19) The protective effects of glutathione against methylmercury cytotoxicity. Kromidas L, Trombetta LD, Jamall IS. Toxicol Lett. 1990 Mar;51(1):67-80.
20) The alcoholic lung: epidemiology, pathophysiology, and potential therapies. Joshi PC, Guidot DM. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L813-23. Epub 2007 Jan 12. Review.
21) High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie J Jr, Mastropaolo W, Murrell SA. J Lab Clin Med. 2002 Dec;140(6):413-7.
22) Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Fernandez-Checa JC, Kaplowitz N. Toxicol Appl Pharmacol. 2005 May 1;204(3):263-73. Review.
24) The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells. Grey A, Banovic T, Zhu Q, Watson M, Callon K, Palmano K, Ross J, Naot D, Reid IR, Cornish J. Mol Endocrinol. 2004 Sep;18(9):2268-78. Epub 2004 Jun 3.
25) The promise and perils of antioxidants for cancer patients. Chandel NS, Tuveson DA. N Engl J Med. 2014 Jul 10;371(2):177-8. doi: 10.1056/NEJMcibr1405701.
26) Antioxidants accelerate lung cancer progression in mice. Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Sci Transl Med. 2014 Jan 29;6(221):221ra15
