CILTEP Nootropic Stack

Contains:

• One bottle with 60 CILTEP capsules

Amount per 3 capsules
Vitamin B-6	5 mg
Extracts from artichoke	900 mg
Coleus forskohlii root extract (standardized to contain 20% forskolin - 4 mg)	20 mg
L-phenylalanine	500 mg
Acetyl-L-Carnitine	750 mg
Other Ingredients: Vegetable capsule, cellulose, vegetable stearate and silica.

 

Serving size:
One dose is equivalent to 2-3 capsules, which are taken on an empty stomach immediately upon waking. Do not take more than 3 capsules per day.

CILTEP tillverkas enligt GMP-standard.

Storage:
Dry and cool at room temperature out of reach from children.

Warning:
Do not consume nicotine or prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you'll have or suspect a medical condition or take any medications. People with the disease phenylketonuria (PKU) - the product contains phenylalanine. Recommended daily dose should not be exceeded. Do not use if safety seal is broken or missing. Store in a cool dry place. Keep Out of Reach of Children.

 

"Nootropic" is the term for supplements that are said to improve our mental abilities such as concentration and memory. CILTEP is included in this category and has quickly become very popular around the world. It is also unique in being fully permitted in Sweden, unlike several other known nootropics.

Read more: Memory Champion Mattias Ribbings blind test of CILTEP

Function

The development of CILTEP was inspired by Nobel Prize winner Eric Kandel's work. He discovered how synapses efficacy can be changed and which molecular mechanisms that are involved in this. Kandel also showed how synaptic function are central for memory and learning. One of Kandel's discoveries showes how the molecular building block cAMP (cyclic adenosine monophosphate) plays a central role in the formation of memories. cAMP acts as a second messenger for several neurotransmitters and hormones inside the cells. cAMP is degraded by the enzyme phosphodiesterase type 4 (PDE4).

Kandel's research team got astounding results when they managed to medically prevent PDE4s breakdown of cAMP in mice. The mice suddenly began to navigate faster in the mazes (1). This was the start that made PDE4 inhibitors to a new research area where one could observe everything from better memory (2) and neuron-protective effect (3) (4), increased alertness (5) and anti-inflammatory properties (6). The ability to treat a variety of brain-related disorders have also been investigated (7).

The idea behind CILTEP was to produce an optimal combination of natural ingredients that inhibit PDE4 and prolongs the time that cAMP is present in the cells. cAMP activates a protein called CREB, which has a well-documented role in the plasticity of the brain cells and the formation of long term memory (8). CREB is important for so-called Long-term potentiation (LTP) (9), which is the persistent strengthening of simultaneous activation of the synapses in the brain. This is considered by many to be physiologically essential in creating memories. The word CILTEP is short for Chemically Induced Long term potentiation.


Ingredients:

Artichoke extract contains the substance luteolin (10) that has been shown to act as effective inhibitors of PDE4 (11). It also inhibits PDE type 1 to 5, which has been shown to promote synaptic plasticity and memory (12) (13).

Forskolin is produced from the plant Makandi and has long been used in traditional Ayurvedic medicine. The topic has been studied comprehensively in modern research and it has been shown effective in increase the levels of cAMP in the cells (14). Forskolin is  paired with luteolinet to work together for a stronger effect.

L-Phenylalanine is an essential amino acid and a natural precursor to dopamine. When CREB is activated, cells increase their dopamine metabolism trough the activation of the enzyme tyrosine hydroxylase (15). L-phenylalanine is added to provide necessary fuel.

Vitamin B6 is required for the conversion of L-fenylalnin into dopamine. The substance is included in the "stack" to achieve the optimal dopamine levels in the higher turn-over during the CREB-enabled LTP.

Acetyl L-carnitine is a form of the amino acid L-carnitine. Both are found in food and can be produced by the liver. Acetyl L-carnitine has been shown to increase levels of the neurotransmitter acetylcholine in the brain (16). cAMP activated forskolin increases the levels of the enzyme acetylcholinesterase (17), which breaks down acetylcholine. Acetyl-l-carnitine has therefor been added to counteract this and can theoretically provide increased energy and better short-term memory.

/ Mattias Ribbing

 

Referenses

1) http://www.forbes.com/global/2002/0204/060.html

 

2) Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. (1998). "Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory". Proceedings of the National Academy of Sciences of the United States of America 95 (25): 15020–5. PMID 9844008

 

3) Block F, Schmidt W, Nolden-Koch M, Schwarz M. (2001). "Rolipram reduces excitotoxic neuronal damage". Neuroreport. 12 (7): 1507–11. PMID 11388438.

 

4) Chen RW, Williams AJ, Liao Z, Yao C, Tortella FC, Dave JR. (2007). "Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation". Neuroscience Letters. 418 (2): 165–9. PMID 17398001.

 

5) Lelkes Z, Alföldi P, Erdos A, Benedek G. (1998). "Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats". Pharmacology, Biochemistry and Behaviour. 60 (4): 835–9. PMID 9700966.

 

6) "Intracellular Mechanisms of Inflammation:PDE4 Promotes the Release of Proinflammatory Mediators". Celgene Corporation. 2012. Retrieved 2012-07-24.

 

7) http://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor

 

8) http://en.wikipedia.org/wiki/CREB

 

9) Kida S. A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP. Exp Neurobiol. 2012;21(4):136-40. PMID 23319873

 

10) Brown JE, Rice-evans CA. Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res. 1998;29(3):247-55. PMID 9802556

 

11) Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

 

12) Kitagawa Y, Hirano T, Kawaguchi SY. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 2009;5:280. PMID 19536203

 

13) Puzzo D, Sapienza S, Arancio O, Palmeri A. Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat. 2008;4(2):371-87. PMID 18728748

 

14) Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 6278005

 

15) Piech-dumas KM, Tank AW. CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of an antisense RNA strategy to produce CREB-deficient PC12 cell lines. Brain Res Mol Brain Res. 1999;70(2):219-30. PMID 10407170

 

16) White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990;15(6):597-601. PMID 2215852

 

17) Curtin BF, Pal N, Gordon RK, Nambiar MP. Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells. Mol Cell Biochem. 2006;290(1-2):23- 32. PMID 16924422